{"id":2350,"date":"2026-05-04T06:51:29","date_gmt":"2026-05-04T06:51:29","guid":{"rendered":"https:\/\/unimed.bg\/?p=2350"},"modified":"2026-05-04T06:51:31","modified_gmt":"2026-05-04T06:51:31","slug":"novi-podhodi-pri-vazpalitelni-chrevni-zabolyavaniya-rolyata-na-mikrobioma-i-faecalibacterium-prausnitzii","status":"publish","type":"post","link":"https:\/\/unimed.bg\/en\/novi-podhodi-pri-vazpalitelni-chrevni-zabolyavaniya-rolyata-na-mikrobioma-i-faecalibacterium-prausnitzii\/","title":{"rendered":"New approaches to inflammatory bowel disease: the role of the microbiome and Faecalibacterium prausnitzii"},"content":{"rendered":"<p class=\"wp-block-paragraph\">Inflammatory bowel disease (IBD), including <strong>ulcerative colitis<\/strong> \u0438 <strong>Crohn's disease<\/strong>, are chronic conditions that can significantly impair quality of life. They are characterised by persistent inflammation of the intestinal mucosa leading to symptoms such as diarrhoea, pain, bleeding and fatigue.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In recent years, science has turned its attention to the gut microbiome as a key factor in the development and treatment of these diseases.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What is the role of the microbiome in IBD<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The gut microbiome is a complex ecosystem of bacteria involved in:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>regulation of the immune system<\/li>\n\n\n\n<li>the maintenance of the intestinal barrier<\/li>\n\n\n\n<li>the control of inflammatory processes<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">In patients with ulcerative colitis and Crohn's disease, it is often seen <strong>dysbiosis<\/strong> - disturbed balance of intestinal bacteria.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What is <em>Faecalibacterium prausnitzii<\/em><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">One of the most studied \u201ebeneficial\u201c bacteria is <em>Faecalibacterium prausnitzii<\/em> - a type that is usually abundant in healthy people but is often reduced in patients with inflammatory bowel disease.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This bacterium is related to:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>anti-inflammatory effects<\/li>\n\n\n\n<li>maintenance of the intestinal barrier<\/li>\n\n\n\n<li>production of important metabolites<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Mechanism of action: why this bacterium is important<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><em>Faecalibacterium prausnitzii<\/em> produces <strong>butyrate<\/strong> - a short-chain fatty acid that:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>serves as the main energy source for the cells of the intestine<\/li>\n\n\n\n<li>supports the recovery of intestinal mucosa<\/li>\n\n\n\n<li>reduces inflammatory processes<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">In addition, it participates in:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>strengthening the intestinal barrier<\/li>\n\n\n\n<li>stimulation of regulatory T-cells (key for control of the immune response)<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the latest research shows<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Contemporary clinical research is examining the possibility of <strong>restoration of this bacteria through targeted therapies<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The results show:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>improvement of symptoms in some patients<\/li>\n\n\n\n<li>reduction of inflammation<\/li>\n\n\n\n<li>better microbiome balance<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Although the data are promising, it is important to highlight:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">- these approaches are still evolving<br>- do not replace standard treatment<br>- require individual medical assessment<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How this relates to fecal microtransplantation (FMT)<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">One way to restore missing bacteria in the microbiome is by <strong>fecal microbiota transplantation (FMT)<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">FMT aims to:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>to restore the overall microbiome balance<\/li>\n\n\n\n<li>to introduce beneficial bacteria, including such as <em>Faecalibacterium prausnitzii<\/em><\/li>\n\n\n\n<li>to help reduce inflammation<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">This approach is being actively investigated in patients with IBD.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">The future: personalized microbiome medicine<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Increasingly, the concept of personalized medicine is evolving, where:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>the individual microbiome is analysed<\/li>\n\n\n\n<li>missing or reduced bacteria are identified<\/li>\n\n\n\n<li>targeted therapies are applied<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">This may include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>specific probiotics<\/li>\n\n\n\n<li>microbiome therapies<\/li>\n\n\n\n<li>FMT in appropriate cases<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">When to seek advice<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">If you suffer from:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>ulcerative colitis<\/li>\n\n\n\n<li>Crohn's disease<\/li>\n\n\n\n<li>chronic intestinal symptoms<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">and standard treatment does not give the desired result, it may be useful to discuss the possibilities of a microbiome approach with a specialist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Conclusion<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Restoring the gut microbiome, including bacteria such as <em>Faecalibacterium prausnitzii<\/em>, is one of the most promising directions in modern medicine. Although these therapies are still in development, they open up new possibilities for a more holistic and individualized approach to inflammatory bowel disease.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Source: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41553310\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/41553310\/<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>\u0412\u044a\u0437\u043f\u0430\u043b\u0438\u0442\u0435\u043b\u043d\u0438\u0442\u0435 \u0447\u0440\u0435\u0432\u043d\u0438 \u0437\u0430\u0431\u043e\u043b\u044f\u0432\u0430\u043d\u0438\u044f (IBD), \u0432\u043a\u043b\u044e\u0447\u0438\u0442\u0435\u043b\u043d\u043e \u0443\u043b\u0446\u0435\u0440\u043e\u0437\u0435\u043d \u043a\u043e\u043b\u0438\u0442 \u0438 \u0431\u043e\u043b\u0435\u0441\u0442 \u043d\u0430 \u041a\u0440\u043e\u043d, \u0441\u0430 \u0445\u0440\u043e\u043d\u0438\u0447\u043d\u0438 \u0441\u044a\u0441\u0442\u043e\u044f\u043d\u0438\u044f, \u043a\u043e\u0438\u0442\u043e \u043c\u043e\u0433\u0430\u0442 \u0437\u043d\u0430\u0447\u0438\u0442\u0435\u043b\u043d\u043e \u0434\u0430 \u0432\u043b\u043e\u0448\u0430\u0442 \u043a\u0430\u0447\u0435\u0441\u0442\u0432\u043e\u0442\u043e \u043d\u0430 \u0436\u0438\u0432\u043e\u0442. \u0422\u0435 \u0441\u0435 \u0445\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u0438\u0437\u0438\u0440\u0430\u0442 \u0441 \u043f\u0435\u0440\u0441\u0438\u0441\u0442\u0438\u0440\u0430\u0449\u043e \u0432\u044a\u0437\u043f\u0430\u043b\u0435\u043d\u0438\u0435 \u043d\u0430 \u0447\u0440\u0435\u0432\u043d\u0430\u0442\u0430 \u043b\u0438\u0433\u0430\u0432\u0438\u0446\u0430, \u0432\u043e\u0434\u0435\u0449\u043e \u0434\u043e \u0441\u0438\u043c\u043f\u0442\u043e\u043c\u0438 \u043a\u0430\u0442\u043e \u0434\u0438\u0430\u0440\u0438\u044f, \u0431\u043e\u043b\u043a\u0430, \u043a\u044a\u0440\u0432\u0435\u043d\u0435 \u0438 \u0443\u043c\u043e\u0440\u0430. \u041f\u0440\u0435\u0437 \u043f\u043e\u0441\u043b\u0435\u0434\u043d\u0438\u0442\u0435 \u0433\u043e\u0434\u0438\u043d\u0438 \u043d\u0430\u0443\u043a\u0430\u0442\u0430 \u043d\u0430\u0441\u043e\u0447\u0432\u0430 \u0432\u043d\u0438\u043c\u0430\u043d\u0438\u0435\u0442\u043e \u0441\u0438 \u043a\u044a\u043c \u0447\u0440\u0435\u0432\u043d\u0438\u044f \u043c\u0438\u043a\u0440\u043e\u0431\u0438\u043e\u043c \u043a\u0430\u0442\u043e \u043a\u043b\u044e\u0447\u043e\u0432 \u0444\u0430\u043a\u0442\u043e\u0440 \u0432 \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u0435\u0442\u043e [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":2266,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_seopress_titles_title":"\u041d\u043e\u0432\u0438 \u043f\u043e\u0434\u0445\u043e\u0434\u0438 \u043f\u0440\u0438 \u0432\u044a\u0437\u043f\u0430\u043b\u0438\u0442\u0435\u043b\u043d\u0438 \u0447\u0440\u0435\u0432\u043d\u0438 \u0437\u0430\u0431\u043e\u043b\u044f\u0432\u0430\u043d\u0438\u044f: \u0440\u043e\u043b\u044f\u0442\u0430 \u043d\u0430 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